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李蕾,AG真人国际,博士生导师,副教授
教育经历:
1994/9-1998/7 中山大学 微生物专业 学士
2000/9-2005/12 武汉大学 病毒学国家重点实验室 博士
工作经历:
2005/12-至今 AG真人国际 同济医学院AG真人国际
2011/08-2013/08国家公派在美国UCSFAG真人国际做访问学者
主要研究方向及成果:
①围绕着肝癌的发病机制进行研究,通过分子生物学及细胞生物学的方法探索肝癌发生发展涉及的主要信号通路及靶点;
②在国内首次创建了新型原位肝癌的转基因小鼠模型,相关研究结果以通讯作者或者第一作者发表在肝脏学权威杂志Journal ofHepatology及Hepatology上;
③药物评价;
④围绕创新型核酸检测系统进行产品研发及产业化。
作为负责人主持的科研项目及人才计划项目情况:
1、国家自然科学基金面上项目:《Slc27a2/5介导的外源脂肪酸摄取在肝内胆管癌发生中的作用及靶向阻断研究》(批准号:81872253;60万元)在研
2、国家自然科学基金青年资助项目:《脂肪代谢途径在癌基因Akt/Ras诱导的 肝癌发生中的作用初探》(批准号:81201553;23万)已结题
3、AG真人国际自主创新研究基金面上项目《FASN调控的脂肪代谢异常在 PI3K/Ras诱导的HCC中的作用机制研究》(8万)在研
4、AG真人国际自主创新研究基金创新交叉重点团队项目(分项目)《肿瘤糖脂代谢关键调控分子挖掘及其抑制剂研究》(30万)在研
5、武汉市晨光计划,20091381,抗呼吸道合胞病毒RSV感染的新药物作用靶点的筛选,2009/01-2013/09,7.5万元,已结题,
6、AG真人国际自主创新基金青年教师基金项目,514/0118514068,Yap在原癌基因所引发的肝细胞癌和肝内胆管细胞癌形成中的分子作用机制研究,2015/01-2016/12,2.5万,已结题
7、AG真人国际自主创新基金,24514005,利用新型小鼠模型研究pten在抑制肝癌发生中的作用机制,2011/06-2012/12,5万元,已结题
8、AG真人国际医科科学研究基金,25514009,靶向抑制呼吸道合胞病毒感染的研究,2008/01-2009/12,2万元,已结题
近期以第一作者或者通讯作者发表的论文
(1) Tingjie Wang,Chuanrui Xu,Zhijing Zhang,Hua Wu,Xiujuan Li,Yu Zhang,Nan Deng,Ningxin Dang,Guangbo Tang,Xiaofei Yang,Bingyin Shi,Zihang Li,Lei Li*,Kai Ye.Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progressionHepatology. First published: 27 March 2022https://doi.org/10.1002/hep.32483(影响因子为17.425)(并被该杂志选为2022年11月份刊封面故事)
(2) Hua Wu , Yuyuan Chen , Bin Li , Chun Li , Jun Guo , Jia You , Xian Hu , Dong Kuang , Shibo Qi , Pin Liu ,Lei Li*, Chuanrui Xu*. Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma. Biochem Pharmacol. 2021 Feb;184:114353. PMID: 33278350(影响因子为5.858)
(3)Li L#, Pilo GM#, Li X#, Cigliano A, Latte G, Che L, Joseph C, Mela M, Wang C, Jiang L, Ribback S, Simile MM, Pascale RM, Dombrowski F, Evert M, Semenkovich CF, Chen X, Calvisi DF*. Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.Journal of Hepatology2016 Feb;64(2):333-341.(影响因子为30.083)
(4)Li L#, Li Che#, Kevin M. Tharp, Hyo-Min Park, Maria G. Pilo,Dan Cao,Antonio Cigliano, Gavinella Latte, Zhong Xu, Silvia Ribback,Frank Dombrowski, Matthias Evert,Gregory J. Gores, Andreas Stahl*, Diego F. Calvisi*,and Xin Chen*.Differential requirement for de novo Lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.Hepatology. 2016 Feb 22. doi: 10.1002/hep.28508.(影响因子为17.425)
(5) Cao Dan, Song Xinhua, Che Li, Li Xiaolei, Pilo Maria G, Vidili Gianpaolo, Porcu Alberto, Solinas Antonio, Cigliano Antonio,Pes Giovanni M, Ribback Silvia, Dombrowski Frank, Chen Xin,Li Lei*, Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells ,Liver International, 2017.1, 37(1): 80~89(影响因子为5.828)
(6) Xue Huiying,Yu Zhaoyang,Liu Yong,Yuan Weigang,Yang Tan,You Jia,He Xingxing,Lee Robert J,Li Lei*,Xu Chuanrui*, Delivery of miR-375 and Doxorubicin by Lipid-Coated Hollow Mesoporous Silica Nanoparticles to Overcome Multiple Drug Resistance in Hepatocellular Carcinoma .InternationalJournal of Nanomedicine, 2017, 12: 5271~5287(影响因子为6.4)
(7) Cigliano Antonio#, Pilo Maria G#, Latte Gavinella#,Li, Lei#, Szydlowska Marta, Simile Maria M, Paliogiannis Panagiotis, Che Li, Pes Giovanni M, Palmieri Giuseppe, Sini Maria C, Cossu Antonio, Porcu Alberto, Vidili Gianpaolo, Seddaiu Maria A, Pascale Rosa M, Ribback Silvia, Dombrowski Frank, Chen Xin, Calvisi Diego F, Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis,Oncotarget, 2017.10.31, 8(53): 90638~90650(影响因子为5.162)
(8) Junjie Hu#, Li Che#,Lei Li#, Giulia M. Pilo, Antonio Cigliano, Ribback S, Li X, Latte G, Mela M, Evert M,Dombrowski F, Zheng G*, Chen X*, Calvisi DF*. Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via mTORC1/FASN pathway in mice.Scientific reports. 2016 Feb 9;6:20484.(影响因子为4.011)
(9) Xue Hui-Ying, Liu Yong, Liao Jia-Zhi, Lin Ju-Sheng, Li Bin, Yuan Wei-Gang, Lee Robert J,Li Lei*, Xu Chuan-Rui*, He Xing-Xing*, Gold nanoparticles delivered miR-375 for treatment of hepatocellular carcinoma,Oncotarget, 2016.12.27, 7(52): 86675~86686(影响因子为5.162)
(10) Hu Linzhen#, Zhu Hucheng#,Li Lei#, Weiguang Liu, Junjun Li, Hua Luo, Zengwei Wang, Jianping, Xue Yongbo, Zhang Yu, Zhang Yonghui, (+/-)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum ,Scientific Reports, 2016.6.8, 6(影响因子为4.011)
(11)Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X*, Seo Y*. [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.Molecular Imaging and Biology. 2015 Nov 13. doi: 10.1007/s11307-015-0915-8.(影响因子为3.341)
(12)Li L#,Wang C#, Calvisi DF, Evert M, Pilo MG,Jiang L,Yuneva M,Chen X*. SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice.PLoS One2013 Sep 19;8(9):e75104.(影响因子为2.776)