Li S, Yuan H, Yang K, Li Q,Xiang M*. Pancreatic sympathetic innervation disturbance in type 1 diabetes. Clin Immunol. 2023 May;250:109319. doi: 10.1016/j.clim.2023.109319. (* correspondence author)
Tian C, Yuan H, Lu Y, He H, Li Q, Li S, Yang J, Wang M, Xu R, Liu Q,Xiang M*. CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport. Oncoimmunology. 2023 Apr 19;12(1):2204015. doi: 10.1080/2162402X.2023.2204015.
Yang J, He J, Feng Y,Xiang M*. Obesity contributes to hepatocellular carcinoma development via immunosuppressive microenvironment remodeling. Front Immunol. 2023 May 17;14:1166440. doi: 10.3389/fimmu.2023.1166440.
Yang J, Li S, He J, Xu Q, Xie M, Yang C, Wang H, Zhang Y, Wan Q,Xiang M*. Dual role of PID1 in regulating apoptosis induced by distinct anticancer-agents through AKT/Raf-1-dependent pathway in hepatocellular carcinoma. Cell Death Discov. 2023 Apr 28;9(1):139. doi: 10.1038/s41420-023-01405-1.
Li Q, He J, Li S, Tian C, Yang J, Yuan H, Lu Y, Fagone P, Nicoletti F,Xiang M*. The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1 / NF-κB pathway. Clin Immunol. 2023 Mar;248:109217. doi: 10.1016/j.clim.2022.109217.
Huang R, Wang B, He J, Zhang Z, Xie R, Li S, Li Q, Tian C, Tuo Y, Zheng R, Chen W,Xiang M*. Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation. J Ethnopharmacol. 2023 Apr 24;306:116060. doi: 10.1016/j.jep.2022.116060.
Yang K, Tian C, Zhang C,Xiang M*. The Controversial Role of IL-33 in Lung Cancer.Front Immunol. 2022;13:897356. 2022 May 12. doi:10.3389/fimmu.2022.897356.
Lu Y#, Zhang P#, Chen H, Tong Q, Wang J, Li Q, Tian C, Yang J, Li S, Zhang Z, Yuan H,Xiang M*. Cytochalasin Q exerts anti-melanoma effect by inhibiting creatine kinase B. Toxicol Appl Pharmacol.2022 Apr 15;441:115971. doi: 10.1016/j.taap.2022.115971.
Xiang M*, Liu T, Tian C, Ma K, Gou J, Huang R, Li S, Li Q, Xu C, Li L, Lee CH, Zhang Y. Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway. Pharmacol Res. 2022 Mar;177:106092. doi: 10.1016/j.phrs.2022.106092.
Li S, Zhou H, Xie M, Zhang Z, Gou J, Yang J, Tian C, Ma K, Wang CY, Lu Y, Li Q, Peng W,Xiang M*. Regenerating islet-derived protein 3 gamma (Reg3g) ameliorates tacrolimus-induced pancreatic β-cell dysfunction in mice by restoring mitochondrial function. Br J Pharmacol. 2022 Jan 20. doi: 10.1111/bph.15803.
Li Q,Xiang M*. Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy. Acta Pharmacol Sin. 2021 Sep 24. doi: 10.1038/s41401-021-00776-4.
Tian C,Xiang M*.Therapeutic agents against COVID-19 with clinical evidence.Curr Pharm Des. 2021, Jan 14;27:1-10.doi: 10.2174/1381612827666210114150951.
Tuo Y, Tian C, Lu L,Xiang M*.The paradoxical role of methionine enkephalin in tumor responses. Eur J Pharmacol. 2020 Sep 5;882:173253. doi: 10.1016/j.ejphar.2020.173253.
Tuo Y, Zhang Z, Tian C, Hu Q, Xie R, Yang J, Zhou H, Lu L,Xiang M*. Anti-inflammatory and metabolic reprogramming effects of MENK produce antitumor response in CT26 tumor-bearing mice. J Leukoc Biol. 2020 Jul;108(1):215-228. doi: 10.1002/JLB.3MA0120-578R.
Tian C, Tuo YL, Lu Y, Xu CR,Xiang M*. The Role of CARD9 in Metabolic Diseases. Curr Med Sci. 2020 Apr;40(2):199-205. doi: 10.1007/s11596-020-2166-4.
Li S, Qian Y, Xie R, Li Y, Jia Z, Zhang Z, Huang R, Tuo L, Quan Y, Yu Z, Liu J,Xiang M*. Exploring the protective effect of ShengMai-Yin and Ganmaidazao decoction combination against type 2 diabetes mellitus with nonalcoholic fatty liver disease by network pharmacology and validation in KKAy mice. J Ethnopharmacol. 2019 Oct 5;242:112029. doi: 10.1016/j.jep.2019.112029.
Tuo Y,Xiang M*. mTOR: A double-edged sword for diabetes. J Leukoc Biol. 2019 Aug;106(2):385-395. doi: 10.1002/JLB.3MR0317-095RR.
Qian Y, Huang R, Li S, Xie R, Qian B, Zhang Z, Li L, Wang B, Tian C, Yang J,Xiang M*.Ginsenoside Rh2 reverses cyclophosphamide-induced immune deficiency by regulating fatty acid metabolism. J Leukoc Biol. 2019 Jun 18. doi: 10.1002/JLB.2A0419-117R.
Zhou Z, Chen H, Xie R, Wang H, Li S, Xu Q, Xu N, Cheng Q, Qian Y, Huang R, Shao Z,Xiang M*. Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer, Mol Oncol, 2019 Apr;13(4):873-893.
Tuo Y,Xiang M*. mTOR: A double-edged sword for diabetes. J Leukoc Biol.2018 Mar 26. doi: 10.1002/JLB.3MR0317-095RR.
Cao H, Li S, Xie R, Xu N, Qian Y, Chen H, Hu Q, Quan Y, Yu Z, Liu J,Xiang M*. Exploring the Mechanism of Dangguiliuhuang Decoction Against Hepatic Fibrosis by Network Pharmacology and Experimental Validation. Front Pharmacol. 2018 Mar 5;9:187. doi: 10.3389/fphar.2018.00187.
Liu X, Zhou Z, Cheng Q, Wang H, Cao H, Xu Q, Tuo Y, Jiang L, Zou Y, Ren H,Xiang M*.Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression.Cell Death Dis. 2017 Sep 7;8(9):e3033. doi: 10.1038/cddis.2017.424.
Cao H, Tuo L, Tuo Y, Xia Z, Fu R, Liu Y, Quan Y, Liu J, Yu Z,Xiang M*. Immune and Metabolic Regulation Mechanism of Dangguiliuhuang Decoction against Insulin Resistance and Hepatic Steatosis. Front Pharmacol. 2017 Jul 7;8:445. doi: 10.3389/fphar.2017.00445.
Xiang M, Liu T, Tan W, Ren H, Li H, Liu J, Cao H, Cheng Q, Liu X, Zhu H, Tuo Y, Wang J, Zhang Y.Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8+T cells communication.Hepatology.2016 Dec 64(6):2135-2150. doi: 10.1002/hep.28825.
Xia F, Cao H, Du J, Liu X, Liu Y,Xiang M*. Reg3g overexpression promotes β cell regeneration and induces immune tolerance in nonobese-diabetic mouse model. J Leukoc Biol. 2016 Jun; 99(6):1131-40. doi: 10.1189/jlb.3A0815-371RRR.
Xu QQ, Fu R, Yin GX, Liu XL, Liu Y,Xiang M*. Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. Gene.2016 Mar 10; 578(2):263-73. doi: 10.1016/j.gene.2015.12.039.
Liu X,Wang J,Wang H,Yin G,Liu Y,Lei X,Xiang M*. REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop.Cancer Lett.2015 Jun 28; 362(1): 45-60. doi: 10.1016/j.canlet.2015.03.014.
Cao H, Lu J, Du J, Xia F, Wei S, Liu X, Liu T, Liu Y,Xiang M*.TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice.Sci Rep. 2015 Oct 13;5:14593. doi: 10.1038/srep14593.
Wang J,Cao H,Wang H,Yin G,Du J,Xia F,Lu J,Xiang M*. Multiple mechanisms involved in diabetes protection by lipopolysaccharide in non-obese diabetic mice.Toxicol Appl Pharmacol.2015 Jun 15;285 (3):149-58. doi:1016/j.taap. 2015. 04. 006.
Liu T,Cao H,Ji Y,Pei Y,Yu Z,Quan Y*,Xiang M*. Interaction of dendritic cells and T lymphocytes for the therapeutic effect of Dangguiliuhuang decoction to autoimmune diabetes.Sci Rep.2015 Sep 11; 5:13982. doi: 10.1038/srep13982.
Cao H, Ji Y, Li W, Liu Y, Fu R,Xiang M*. Protective Effects of the Total Coumarin Fraction of Urticadentata on Experimental Diabetic Nephropathy In Vitro and In Vivo. Planta Med. 2015 Oct; 81(15):1353-60. doi: 10.1055/s-0035-1557866.
Yin G, Du J, Cao H, Liu X, Xu Q,Xiang M*. Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis.Digest Dis Sci. 2015Dec; 60(12):3656-68. doi: 10.1007/s10620-015-3787-5.
Wang J, Zhou H, Han Y, Liu X, Wang M, Wang X, Yin G, Li X,Xiang M*.SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer.J Mol Med. 2014 Jul 5; 92(12):1257-69. doi: 10.1007/s00109-014-1184-8.
Wang J, Xiang M*. Targeting potassium channels Kv1.3 and KC a 3.1: routes to selective immunomodulators in autoimmune disorder treatment? Pharmacotherapy. 2013 May;33(5):515-28. doi: 10.1002/phar.1236.
Wang J, Lu J, Lan Y, Zhou H, Li W,Xiang M*. Total coumarins from Urticadentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways. J Ethnopharmacol. 2013 Mar 7;146(1):379-92.
Xiang M, Lu J, Zhang C, Lan Y, Zhou H, Li X, Peng W. Identification and quantification of total coumarins from Urticadentata Hand and its roles in promoting immune tolerance via TLR4-mediated dendritic cell immaturation. Biosci.Biotechnol.Biochem. 2013 Jun 23;77(6):1200-6.
Xie S,Feng J,Yu C,Li Z,Wu Y,Cao Z,Li W,He X,Xiang M*,Han S. Identification of a new specific Kv1.3 channel blocker, Ctri9577, from the scorpion Chaerilustricostatus.Peptides.2012 Jul;36(1):94-9.
Lu J, Zeng Y, Hou W, Zhang S, Li L, Luo X, Xi W, Chen Z,Xiang M*. The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway. J NutrBiochem. 2012; 23(11):1449-57.
Xiang M, Zhang S, Lu J, Li L, Hou W, Xie M, Zeng Y. Antilithic effects ofextracts from Urticadentata hand on calcium oxalate urinary stones in rats. J HuazhongUnivSci Technol. 2011; 31(5): 673-677.
Luo X, Li L, Zhang S, Lu J, Zeng Y, Zhang H,Xiang M*. Therapeutic effects of total coumarins from Urticadentata Hand on collagen-induced arthritis in Balb/c mice. J Ethnopharmacol. 2011; 138(2): 523-9.
Hou W, Xie S,Wang HJ, Su YY, Lu JL, Li LL, Zhang SS,Xiang M*. Intramuscular delivery of a naked DNA plasmid encoding proinsulin and pancreatic regenerating III protein ameliorates type 1 diabetes mellitus. Pharmacological Research. 2011; 63(4): 320-327.
Hou W, Su ZQ, Pi HF, Yao GM, Zhang P, Luo X, Xie SN,Xiang M*. Immunosuppressive constituents from Urticadentata Hand. J Asian Nat Prod Res. 2010; 12(8): 707-13.
Xiang M, Hou W, Xie S, Zhang WD, Wang X. Immunosuppressive effects of an ethyl acetate extract from Urticadentata Hand on skin allograft rejection. J Ethnopharmacol. 2009; 126: 57-63.
Zhang C, Zou X, Guan L, Xu J,Xiang M*. Prevention of Type 1 Diabetes by Immature Dendritic Cells Treated with an Ethanol Extract of Paecilomyceshepiali Chen Mycelium. Methods Find ExpClinPharmacol. 2008; 30(6): 421-429.
Zou X,Zhao Z, Wang Y, Su Z,Xiang M*. Diabetogenic T cells induce autoimmune diabetes in BALB/c mice. Chin Med Sci J. 2008; 23(2):88-94.
Xiang M, Zou X, Zhang C, Zhao Z,Xu J. Insulin administration confers diabetes-preventive properties to NOD mice derived dendritic cells. ImmunopharmacolImmunotoxicol. 2007; 29(3-4): 451-64.
Zhang C, Zou X,Xiang M*. Immune tolerance induced by adoptive transfer of DCs in IDDM murine model. ActaPharmacologicaSinica. 2007; 28(1): 98-104
Xiang M, Eisenbach C, Lupu C, Ernst E, Stremmel W,Encke J. Induction of antigen-specific immune responses in vivo after vaccination with dendritic cells transduced with adenoviral vectors encoding hepatitis C virus NS3. Viral Immunology. 2006; 19(2): 210-219.
Xiang M, Zhang C, Zou X, Cai X, Peng J. Roles of dendritic cells and regulatory T cells in autoantigen-induced urine immune tolerance model. World Chinese Journal of Digestive. 2006; 14(7): 687-692.
Xiang M, Eisenbach C, Ernst E, Weigand K, Stremmel W, Encke J. Humoral and cellular immune responses elicited by immunization with genetically modified dendritic cells expressing HCVNS3. Hepatology. 2005; 42 (4) Suppl.1:248A
Nicoletti F, Zaccone P,Xiang M, Magro G, Di Mauro M, Di Marco R, Garotta G, Meroni P. Essential pathogenetic role for interferon (IFN-)gamma in concanavalin -induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine. 2000; 12(4): 315-23.
Nicoletti F, Di Marco R, Zaccone P,Xiang M, Magro G, Grasso S, Morrone S, Santoni A, Shoenfeld Y, Garotta G, Meroni P. Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr / lpr mice. Eur J Immunol. 2000; 30(2): 438-47.
Di Marco R,Xiang M, Zaccone P, Leonardi C, Franco S, Meroni P, Nicoletti F. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity. 1999; 31(2): 75-83.
Xiang M, Zaccone P, Di Marco R, Harris R, Magro G, Di Mauro M, Meroni PL, Garotta G, Nicoletti F. Failure of exogenously administered interferon-gamma or blockage of endogenous interleukin-4 with specific inhibitors to augment the incidence of autoimmune diabetes in male NOD mice. Autoimmunity. 1999; 30(2):71-80.
Xiang M, Zaccone P, Di Marco R, Magro G, Di Mauro M, Beltrami B, Meroni PL, Nicoletti F. Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice. Eur J Pharmacol. 1999; 367(2-3): 399-404.