陈红
研究方向:
1.急性肾损伤和糖尿病肾病的机制研究
2.多肽药物在肾脏疾病中治疗作用研究
3.糖尿病及代谢综合征的机制研究
联系方式:hongchen2017@hust.edu.cn
工作与教育经历:
2019/11-至今,AG真人国际,AG真人国际,副教授
2017/08-2019/11,AG真人国际,AG真人国际,讲师
2014/07-2017/07,AG真人国际,公共卫生学院,博士后
2009/09-2014/06,AG真人国际,AG真人国际,博士
2004/09-2009/06,沈阳药科大学,AG真人国际,学士
主持科研项目:
1. 国家自然科学基金面上项目,32371171,UTX-TRPM6依赖性的镁离子稳态在急性肾损伤中的作用机制研究
2. 湖北省自然科学基金面上项目,组蛋白去甲基化酶UTX对肥胖相关性肾病的调控作用研究
3. 2022年度湖北省生物靶向湖北省重点实验室开放基金
4. 国家自然科学基金青年项目,31500941,脂肪因子Apelin对急性肾损伤的保护机制研究
5. AG真人国际自主创新基金面上项目,ELA多肽在急性肾损伤中的作用研究
6. 中国博士后科学基金第九批特别资助项目,2016T90692,H3K27甲基化在糖尿病肾病中的作用机制研究
7. 中国博士后科学基金面上项目,2015M572149,Apelin对缺血再灌注型急性肾损伤的保护机制研究
参编教材:
《药学分子生物学》人民卫生出版社第六版,编委
《药学分子生物学》学习指导与习题集人民卫生出版社第六版,编委
代表性研究成果:
1. Yang C, Xu H, Yang D, Xie Y, Xiong M, Fan Y, Liu X, Zhang Y, Xiao Y, Chen Y, Zhou Y, Song L, Wang C, Peng A, Petersen RB,Chen H*, Huang K*, Zheng L*. A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury.Nature communications(Accepted). IF= 17.694
2. Xiong M#,Chen H#, Fan Y, Jin M, Yang D, Chen Y , Zhang Y, Petersen R, Su H, Peng A, Wang C, Zheng L*, Huang K*. Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation.Theranostics2023; 13(10):3387-3401. IF= 12.4
3. Chen Hong, Liu Chong, Wang Qian, Xiong Mingrui, Zeng Xia, Yang Dong, Xie Yunhao, Su Hua, Zhang Yu, Huang Yixue, Chen Yuchen, Yue Junqiu, Liu Chengyu, Wang Shun, Huang, Kun*, Zheng Ling*, Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver,Nature communications, 2022 Jul 4;13(1):3835. (IF=17.694)被Natural Review Nephrology评选为Research Highlight
4. Yang Chen#, Zhang Yu#, Zeng Xia, Chen Huijing, Chen Yuchen, Yang Dong, Shen Ziwei, Wang Xiaomu, Liu Xiuran, Xiong Mingrui,Chen Hong*and Huang Kun*, Kidney injury molecule-1 is a potential receptor for SARS-CoV-2.JMol Cell Biol, 2021 Jul 6;13(3):185-196. (IF=8.185)
5. Wang Chao#, Xiong Mingrui#, Yang Chen, Yang Dong, Zheng Jiaojiao, Fan Yu, Wang Shun, Gai Yongkang, Lan Xiaoli,Chen Hong*, Zheng Ling*, Huang Kun*, PEGylated and acylated Elabela analogues show enhanced receptor binding, prolonged stability, and remedy of acute kidney injury.J Med Chem, 2020 Dec 24;63(24):16028-16042. (IF=8.039)
6. Chen Hong#,Huang Yixue#, Zhu Xiuqin, Liu Chong, Yuan Yangmian, Su Hua, Zhang Chun, Liu Chengyu, Xiong Mingrui, Qu Yannan, Yun Peng, Zheng Ling*, Huang Kun *, Histone demethylase UTX is a therapeutic target for diabetic kidney disease,The Journal of Physiology,2019, 597(6):1643-1660. (IF=6.228)
7. Chen Hong, Liu Chengyu, Cheng Cheng, Zheng Ling, Huang Kun*, Effects of apelin peptides on diabetic complications,Curr Protein Pept Sci, 2018, 19(2):179-189. (IF=3.118)
8. Chen Hong,Wang Lin, Wang Wenjun, Cheng Cheng, Zhang Yu, Zhou Yu, Wang Congyi, Miao Xiaoping, Wang Jiao, Wang Chao, Li Jianshuang, Zheng Ling, Huang Kun*, ELABELA and an ELABELA fragment protect against AKI.J Am Soc Nephrol,2017 Sep; 28(9):2694-2707. (IF=14.978)
9. Chen Hong, Wan Danyang, Wang Lin, Peng Anlin, Xiao Hongdou, Petersen R.Bobert, Liu Chengyu,Zheng Ling*, Huang Kun*, Apelin protects against acute renal injury by inhibiting TGF-b1,BBA - Molecular Basis of Disease,2015 Jul; 1852(7):1278-87. (IF=6.633)
10. Chen Hong,Li Jianshuang, Jiao Lihua, Petersen R.Bobert, Li Jiong, Peng Anlin, Zheng Ling*, Huang Kun*, Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse,The Journal of Physiology, 2014, 592, 505-521. (IF=6.228)
11. Chen Hong#, Zheng Chenghong#, Zhang Xin, Li Jianshuang, Li Jiong, Zheng Ling*, Huang Kun*, Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice,Peptides, 2011, 32, 1634-1639. (IF=3.867)